Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 42 Researches
8
USERS' SCORE
Medium or Average
Based on 8 Reviews
6.6
Supplement Facts
Serving Size: One (1) Capsule
Amount Per Serving
%DV
Calories
0
Total Carbohydrate
0 g
0%+
Total Sugars
0 g
**
Incl. 0 g Added Sugars
0%+
A Proprietary Probiotic Blend
154 mg (15 billion CFUs)
Lactobacillus crispatus LBV 88
**
Lactobacillus rhamnosus LBV 96
**
Lactobacillus rhamnosus GG
**
Lactobacillus gasseri LBV 150N
**
Lactobacillus jensenii LBV 116
**
A Proprietary Prebiotic Blend
15 mg
Myoviridae LH01
**
Siphoviridae LL5
**
Myoviridae T4D
**
Myoviridae LL12
**
Top Medical Research Studies
9
We explored how lactic acid bacteria (LAB) can combat the harmful effects of Candida albicans, the fungus responsible for yeast infections. Through our study, we found that the supernatant from LAB like Lactobacillus crispatus and L. gasseri effectively inhibited the growth and harmful activity of C. albicans.
Specifically, L. gasseri showed exceptional ability in preventing the formation of biofilms and hyphae, crucial stages in fungal development. Additionally, the metabolites produced by these bacteria downregulated key genes associated with C. albicans, reinforcing their role in maintaining vaginal health.
Overall, while the findings are promising, further research is needed to confirm the clinical effectiveness of these metabolites in treating or preventing yeast infections.
Specifically, L. gasseri showed exceptional ability in preventing the formation of biofilms and hyphae, crucial stages in fungal development. Additionally, the metabolites produced by these bacteria downregulated key genes associated with C. albicans, reinforcing their role in maintaining vaginal health.
Overall, while the findings are promising, further research is needed to confirm the clinical effectiveness of these metabolites in treating or preventing yeast infections.
Read More
8
We explored how Limosilactobacillus fermentum KBL674 impacts vaginal candidiasis, commonly caused by Candida albicans. In a mouse model, this probiotic strain significantly inhibited C. albicans growth and alleviated symptoms like tissue swelling and immune response. Interestingly, many of the administered L. fermentum KBL674 didn't remain in the gut; it altered gut bacteria diversity, linking these changes to reduced yeast infection severity. Overall, our findings suggest that L. fermentum KBL674 may offer a promising approach to help manage yeast infections.
Read More
8
We investigated how lactobacillus probiotics could restore the vaginal and gut microbiota of pregnant women dealing with vaginal candidiasis. In a well-structured randomized study with 78 participants, we compared a probiotic with a placebo over eight weeks.
Our findings showed that those receiving the probiotic had stable microbiota, unlike those on the placebo, who experienced significant shifts. This suggests lactobacillus can help maintain a healthy microbial balance, which is essential for health during pregnancy. Overall, lactobacillus probiotics offer promising benefits in managing yeast infections.
Our findings showed that those receiving the probiotic had stable microbiota, unlike those on the placebo, who experienced significant shifts. This suggests lactobacillus can help maintain a healthy microbial balance, which is essential for health during pregnancy. Overall, lactobacillus probiotics offer promising benefits in managing yeast infections.
Read More
Most Useful Reviews
9
Solved problems.
19 people found this helpful
Works great! My chronic yeast infections while on antibiotics and some gastric discomfort disappeared after just a short time on this probiotic. My PCP recommended it, and I'm delighted I tried it. I definitely recommend it. Just one pill a day, easy to swallow, and delivered within two days!
Read More
0
Ineffective treatment.
4 people found this helpful
Doesn't work to prevent or relieve yeast infections or BV. I've had them for years and hoped this product would help. I've taken it for six months, which I believe is ample time for a fair trial.
Read More
9
Reliable probiotic.
3 people found this helpful
Great for my digestive health and female issues! I take one every night and can use the bathroom every morning without fail. They also appear to keep yeast infections at bay. A friend recommended these, and I'm glad I gave them a go. I don't think I'll choose any other probiotic!
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 42 Researches
8
- All Researches
9.5
We investigated the potential of a specific strain of Lactobacillus gasseri, named VHProbi E09, to treat vaginitis and fight off common pathogens causing yeast infections. Through laboratory tests, we found that this strain effectively inhibited the growth of harmful bacteria and yeast by over 99%.
Additionally, it prevented these pathogens from adhering to vaginal cells, showing promise for future clinical applications. While these results are promising, further research is necessary to fully understand its effectiveness in clinical settings and its role in restoring normal vaginal flora.
Additionally, it prevented these pathogens from adhering to vaginal cells, showing promise for future clinical applications. While these results are promising, further research is necessary to fully understand its effectiveness in clinical settings and its role in restoring normal vaginal flora.
Read More
9.5
We investigated how Lactobacillus rhamnosus Lcr35, contained in the GYNOPHILUS product, can combat yeast infections like Candida. This study showed that the product’s formulation, enhanced by sodium thiosulfate, improves its ability to kill yeast cells.
Remarkably, after 48 hours of co-culturing, the yeast’s viability dropped to zero. The presence of odor-active sulfur compounds, specifically S-methyl thioacetate, was linked to this antifungal effect.
Interestingly, achieving the full antifungal impact relies on these sulfur components.
Remarkably, after 48 hours of co-culturing, the yeast’s viability dropped to zero. The presence of odor-active sulfur compounds, specifically S-methyl thioacetate, was linked to this antifungal effect.
Interestingly, achieving the full antifungal impact relies on these sulfur components.
Read More
9
We examined a new treatment, VAGINNE, derived from beneficial species to tackle vulvovaginal candidiasis (VVC). Using a mouse model, we observed that VAGINNE improved the balance of the vaginal microbiome while reducing harmful yeast growth.
Additionally, it lowered inflammatory markers in both vaginal tissue and blood, suggesting an anti-inflammatory effect. Our histological analysis showed better tissue integrity in treated mice compared to those without treatment.
These results indicate that VAGINNE can be a promising, side-effect-free alternative to conventional antifungals for managing VVC, especially in cases where drugs fail or cause issues.
Additionally, it lowered inflammatory markers in both vaginal tissue and blood, suggesting an anti-inflammatory effect. Our histological analysis showed better tissue integrity in treated mice compared to those without treatment.
These results indicate that VAGINNE can be a promising, side-effect-free alternative to conventional antifungals for managing VVC, especially in cases where drugs fail or cause issues.
Read More
9
We aimed to understand if adding probiotics to standard antifungal treatment improves outcomes for vulvovaginal candidiasis (VVC). In our study, 60 women diagnosed with VVC were divided into two groups.
One group received just antifungal medication, while the other received both antifungal and probiotic treatments.
Results indicated that those who took probiotics alongside their antifungal showed better improvement and had lower relapse rates. This suggests that probiotics can be a beneficial addition to standard yeast infection treatments.
One group received just antifungal medication, while the other received both antifungal and probiotic treatments.
Results indicated that those who took probiotics alongside their antifungal showed better improvement and had lower relapse rates. This suggests that probiotics can be a beneficial addition to standard yeast infection treatments.
Read More
9
We explored how lactic acid bacteria (LAB) can combat the harmful effects of Candida albicans, the fungus responsible for yeast infections. Through our study, we found that the supernatant from LAB like Lactobacillus crispatus and L. gasseri effectively inhibited the growth and harmful activity of C. albicans.
Specifically, L. gasseri showed exceptional ability in preventing the formation of biofilms and hyphae, crucial stages in fungal development. Additionally, the metabolites produced by these bacteria downregulated key genes associated with C. albicans, reinforcing their role in maintaining vaginal health.
Overall, while the findings are promising, further research is needed to confirm the clinical effectiveness of these metabolites in treating or preventing yeast infections.
Specifically, L. gasseri showed exceptional ability in preventing the formation of biofilms and hyphae, crucial stages in fungal development. Additionally, the metabolites produced by these bacteria downregulated key genes associated with C. albicans, reinforcing their role in maintaining vaginal health.
Overall, while the findings are promising, further research is needed to confirm the clinical effectiveness of these metabolites in treating or preventing yeast infections.
Read More
User Reviews
USERS' SCORE
Medium or Average
Based on 8 Reviews
6.6
- All Reviews
- Positive Reviews
- Negative Reviews
9
Solved problems.
19 people found this helpful
Works great! My chronic yeast infections while on antibiotics and some gastric discomfort disappeared after just a short time on this probiotic. My PCP recommended it, and I'm delighted I tried it. I definitely recommend it. Just one pill a day, easy to swallow, and delivered within two days!
Read More
0
Ineffective treatment.
4 people found this helpful
Doesn't work to prevent or relieve yeast infections or BV. I've had them for years and hoped this product would help. I've taken it for six months, which I believe is ample time for a fair trial.
Read More
9
Reliable probiotic.
3 people found this helpful
Great for my digestive health and female issues! I take one every night and can use the bathroom every morning without fail. They also appear to keep yeast infections at bay. A friend recommended these, and I'm glad I gave them a go. I don't think I'll choose any other probiotic!
Read More
9
Effective prevention.
3 people found this helpful
Best probiotic! No more BV, UTIs, or yeast infections! This pill effectively prevents all of these issues and supports immune, digestive, and vaginal health for sure!
Read More
0
Recurring infection.
3 people found this helpful
Yeast infection. This product gave me a yeast infection. I know it’s the pills since I tried them again later and got another infection. It was a dreadful three months of my life. Never again.
Read More
Frequently Asked Questions
9
We examined the effectiveness of various Lactobacillus strains, particularly Lactobacillus rhamnosus, against yeast infections caused by Candida. Through our analysis, we found that live probiotic cells and their cell-free supernatants showed strong anticandidal activity.
Notably, L. rhamnosus SD11 was especially effective, particularly when supplemented with prebiotics like mangosteen, leading to improved growth and metabolic activity. This suggests that combining probiotics and prebiotics might be a promising alternative treatment for Candida infections.
Notably, L. rhamnosus SD11 was especially effective, particularly when supplemented with prebiotics like mangosteen, leading to improved growth and metabolic activity. This suggests that combining probiotics and prebiotics might be a promising alternative treatment for Candida infections.
8
We examined 15 recent articles on various Lactobacillus strains and their effects on Candida species. Our exploration revealed that certain strains, including Lactobacillus rhamnosus, could inhibit Candida growth and reduce the chance of recurrent yeast infections.
We also learned that using these probiotics for a longer duration tends to yield better results, especially when combined with standard treatments. Though the probiotics showed potential, it's essential to consider the specific strain and usage time for effective results.
We also learned that using these probiotics for a longer duration tends to yield better results, especially when combined with standard treatments. Though the probiotics showed potential, it's essential to consider the specific strain and usage time for effective results.
7
We explored the effectiveness of probiotics for treating vulvovaginal candidiasis through a systematic review and meta-analysis of six randomized control trials. Our thorough search aimed to discover whether probiotics could serve as an effective treatment compared to placebo.
While probiotics didn't show a significant difference in positive culture rates, they did demonstrate a reduction in recurrence of infections. This indicates that while they may not remove the yeast directly, they can aid in preventing future flare-ups. Thus, probiotics might be a helpful option for managing yeast infections.
While probiotics didn't show a significant difference in positive culture rates, they did demonstrate a reduction in recurrence of infections. This indicates that while they may not remove the yeast directly, they can aid in preventing future flare-ups. Thus, probiotics might be a helpful option for managing yeast infections.
1
We investigated the role of oral probiotics in preventing recurrent vulvovaginal infections (VVIs) during pregnancy. In a rigorous multicenter trial, pregnant women with previous infections received either a probiotic or placebo.
Despite the intention to enhance vaginal health, our findings revealed no significant difference in infection rates between the two groups. This indicates that the tested probiotics did not effectively lower the risk of VVIs after treatment.
Thus, for pregnant women, these specific probiotics seem to fall short in combatting recurring infections.
Despite the intention to enhance vaginal health, our findings revealed no significant difference in infection rates between the two groups. This indicates that the tested probiotics did not effectively lower the risk of VVIs after treatment.
Thus, for pregnant women, these specific probiotics seem to fall short in combatting recurring infections.
References
- Nachum Z, Suleiman A, Colodner R, Battino S, Wattad M, et al. Oral Probiotics to Prevent Recurrent Vulvovaginal Infections During Pregnancy-Multicenter Double-Blind, Randomized, Placebo-Controlled Trial. Nutrients. 2025;17. doi:10.3390/nu17030460
- Horng HC, Xu JW, Kuo YS, Chen YS, Chiu YH, et al. Dual Mechanisms of Action: Anti-Candida and Anti-Inflammatory Potential of Fermentation Broth in Treating Vulvovaginal Candidiasis. J Fungi (Basel). 2024;11. doi:10.3390/jof11010018
- Thekho AJ, Mendiratta V, Garg T, Kaur R, Yadav V. Role of Probiotic in Vulvovaginal Candidiasis: A Randomised Controlled Non-blinded Trial from India. Indian J Dermatol. 2024;69:422. doi:10.4103/ijd.ijd_193_24
- Bae WY, Lee YJ, Jo S, Shin SL, Kim TR, et al. Effects of LM1215 on and . Yonsei Med J. 2024;65:727. doi:10.3349/ymj.2023.0490
- Jang SJ, Jo EJ, Lee C, Cho BR, Shin YJ, et al. Limosilactobacillus fermentum KBL674 Alleviates Vaginal Candidiasis. Probiotics Antimicrob Proteins. 2024. doi:10.1007/s12602-024-10403-3
- Vazquez-Munoz R, Thompson A, Sobue T, Dongari-Bagtzoglou A. is a dominant in the murine oral mucosa and has chitinase activity that compromises fungal cell wall integrity. mBio. 2024;15:e0241624. doi:10.1128/mbio.02416-24
- Zhang J, Li K, Cao T, Duan Z. Characterization of a Lactobacillus gasseri strain as a probiotic for female vaginitis. Sci Rep. 2024;14:14426. doi:10.1038/s41598-024-65550-y
- Elsayes SA, El Attar MS, ElHadary A, Aboulela AG, Essawy MM, et al. Antimycotic prophylaxis with multispecies probiotics against oral candidiasis in new complete denture wearers: A randomized clinical trial. J Prosthet Dent. 2024. doi:10.1016/j.prosdent.2024.05.018
- Zahedifard T, Khadivzadeh T, Rakhshkhorshid M. The Role of Probiotics in the Treatment of Vulvovaginal Candidiasis: A Systematic Review and Meta-Analysis. Ethiop J Health Sci. 2023;33:881. doi:10.4314/ejhs.v33i5.18
- Sookkhee S, Khamnoi P, Sastraruji T, Boonkum S, Wikan N, et al. Synergistic Inhibition of Synbiotic Cultures among Lactobacilli and Plant Extracts against Vaginal Discharge Causing . Nutrients. 2024;16. doi:10.3390/nu16091372
- Ang XY, Roslan NS, Ahmad N, Yusof SM, Abdullah N, et al. Lactobacillus probiotics restore vaginal and gut microbiota of pregnant women with vaginal candidiasis. Benef Microbes. 2023;14:421. doi:10.1163/18762891-20220103
- Bertarello C, Savio D, Morelli L, Bouzalov S, Davidova D, et al. Efficacy and safety of Lactobacillus plantarum P 17630 strain soft vaginal capsule in vaginal candidiasis: a randomized non-inferiority clinical trial. Eur Rev Med Pharmacol Sci. 2024;28:384. doi:10.26355/eurrev_202401_34927
- Faustino M, Pereira JO, Pereira AM, Oliveira AS, Ferreira CMH, et al. Vaginal prevention of Candida albicans: synergistic effect of lactobacilli and mannan oligosaccharides (MOS). Appl Microbiol Biotechnol. 2024;108:73. doi:10.1007/s00253-023-12909-2
- Das S, Konwar BK. Inhibiting pathogenicity of vaginal Candida albicans by lactic acid bacteria and MS analysis of their extracellular compounds. APMIS. 2024;132:161. doi:10.1111/apm.13365
- Deshkar S, Yeole P, Mahore J, Shinde A, Giram P. Polyelectrolyte-Complex-Based Hydrogel Inserts for Vaginal Delivery of Posaconazole and Probiotics. Gels. 2023;9. doi:10.3390/gels9110851
- ElFeky DS, Awad AR, Shamseldeen AM, Mowafy HL, Hosny SA. Comparing the therapeutic potentials of vs. against vulvovaginal candidiasis in female rats: an study. Front Microbiol. 2023;14:1222503. doi:10.3389/fmicb.2023.1222503
- Giordani B, Naldi M, Croatti V, Parolin C, Erdoğan Ü, et al. Exopolysaccharides from vaginal lactobacilli modulate microbial biofilms. Microb Cell Fact. 2023;22:45. doi:10.1186/s12934-023-02053-x
- Kumherová M, Veselá K, Kosová M, Mašata J, Horáčková Š, et al. Novel Potential Probiotic Lactobacilli for Prevention and Treatment of Vulvovaginal Infections. Probiotics Antimicrob Proteins. 2021;13:163. doi:10.1007/s12602-020-09675-2
- De Gregorio PR, Parolin C, Abruzzo A, Luppi B, Protti M, et al. Biosurfactant from vaginal Lactobacillus crispatus BC1 as a promising agent to interfere with Candida adhesion. Microb Cell Fact. 2020;19:133. doi:10.1186/s12934-020-01390-5
- Jang SJ, Lee K, Kwon B, You HJ, Ko G. Vaginal lactobacilli inhibit growth and hyphae formation of Candida albicans. Sci Rep. 2019;9:8121. doi:10.1038/s41598-019-44579-4
- Er S, İstanbullu Tosun A, Arık G, Kıvanç M. Anticandidal activities of lactic acid bacteria isolated from the vagina. Turk J Med Sci. 2019;49:375. doi:10.3906/sag-1709-143
- Matsuda Y, Cho O, Sugita T, Ogishima D, Takeda S. Culture Supernatants of Lactobacillus gasseri and L. crispatus Inhibit Candida albicans Biofilm Formation and Adhesion to HeLa Cells. Mycopathologia. 2018;183:691. doi:10.1007/s11046-018-0259-4
- Zhang X, Li T, Niu XX, Wang SX, Liu ZH. [Scanning electron microscopic observation of interactions of vaginal epithelial cells with Candida albicans and Lactobacillus crispatus]. Zhonghua Fu Chan Ke Za Zhi. 2017;52:618. doi:10.3760/cma.j.issn.0529-567X.2017.09.008
- Niu XX, Li T, Zhang X, Wang SX, Liu ZH. Modulates Vaginal Epithelial Cell Innate Response to . Chin Med J (Engl). 2017;130:273. doi:10.4103/0366-6999.198927
- Parolin C, Marangoni A, Laghi L, Foschi C, Ñahui Palomino RA, et al. Isolation of Vaginal Lactobacilli and Characterization of Anti-Candida Activity. PLoS One. 2015;10:e0131220. doi:10.1371/journal.pone.0131220
- Rizzo A, Losacco A, Carratelli CR. Lactobacillus crispatus modulates epithelial cell defense against Candida albicans through Toll-like receptors 2 and 4, interleukin 8 and human β-defensins 2 and 3. Immunol Lett. 2013;156:102. doi:10.1016/j.imlet.2013.08.013
- Chantanawilas P, Pahumunto N, Thananimit S, Teanpaisan R. Anticandidal Activity of Various Probiotic Lactobacillus Strains and Their Efficacy Enhanced by Prebiotic Supplementation. Curr Microbiol. 2024;81:271. doi:10.1007/s00284-024-03800-y
- Pimentel MMNSC, de Carvalho Alves J, Pinheiro LHS, Roselino MN. Potential Action of Probiotics Against Fungi of the Genus : A Bibliographic Review. Recent Pat Biotechnol. 2023;17:198. doi:10.2174/1872208317666221027093644
- Spaggiari L, Sala A, Ardizzoni A, De Seta F, Singh DK, et al. Lactobacillus acidophilus, L. plantarum, L. rhamnosus, and L. reuteri Cell-Free Supernatants Inhibit Candida parapsilosis Pathogenic Potential upon Infection of Vaginal Epithelial Cells Monolayer and in a Transwell Coculture System . Microbiol Spectr. 2022;10:e0269621. doi:10.1128/spectrum.02696-21
- Dausset C, Bornes S, Miquel S, Kondjoyan N, Angenieux M, et al. Identification of sulfur components enhancing the anti-Candida effect of Lactobacillus rhamnosus Lcr35. Sci Rep. 2020;10:17074. doi:10.1038/s41598-020-74027-7
- Poupet C, Saraoui T, Veisseire P, Bonnet M, Dausset C, et al. Lactobacillus rhamnosus Lcr35 as an effective treatment for preventing Candida albicans infection in the invertebrate model Caenorhabditis elegans: First mechanistic insights. PLoS One. 2019;14:e0216184. doi:10.1371/journal.pone.0216184
- Lee X, Vergara C, Lozano CP. Severity of Candida-associated denture stomatitis is improved in institutionalized elders who consume Lactobacillus rhamnosus SP1. Aust Dent J. 2019;64:229. doi:10.1111/adj.12692
- De Gregorio PR, Silva JA, Marchesi A, Nader-Macías MEF. Anti-Candida activity of beneficial vaginal lactobacilli in in vitro assays and in a murine experimental model. FEMS Yeast Res. 2019;19. doi:10.1093/femsyr/foz008
- Leão MVP, Tavares TAA, Gonçalves E Silva CR, Dos Santos SSF, Junqueira JC, et al. Lactobacillus rhamnosus intake can prevent the development of Candidiasis. Clin Oral Investig. 2018;22:2511. doi:10.1007/s00784-018-2347-8
- Rossoni RD, Dos Santos Velloso M, Figueiredo LMA, Martins CP, Jorge AOC, et al. Clinical strains of Lactobacillus reduce the filamentation of Candida albicans and protect Galleria mellonella against experimental candidiasis. Folia Microbiol (Praha). 2018;63:307. doi:10.1007/s12223-017-0569-9
- Tan Y, Leonhard M, Moser D, Ma S, Schneider-Stickler B. Inhibitory effect of probiotic lactobacilli supernatants on single and mixed non-albicans Candida species biofilm. Arch Oral Biol. 2018;85:40. doi:10.1016/j.archoralbio.2017.10.002
- Mailänder-Sánchez D, Braunsdorf C, Grumaz C, Müller C, Lorenz S, et al. Antifungal defense of probiotic Lactobacillus rhamnosus GG is mediated by blocking adhesion and nutrient depletion. PLoS One. 2017;12:e0184438. doi:10.1371/journal.pone.0184438
- de Oliveira FE, Rossoni RD, de Barros PP, Begnini BE, Junqueira JC, et al. Immunomodulatory effects and anti-Candida activity of lactobacilli in macrophages and in invertebrate model of Galleria mellonella. Microb Pathog. 2017;110:603. doi:10.1016/j.micpath.2017.08.006
- Rodríguez-Arias RJ, Guachi-Álvarez BO, Montalvo-Vivero DE, Machado A. Lactobacilli displacement and Candida albicans inhibition on initial adhesion assays: a probiotic analysis. BMC Res Notes. 2022;15:239. doi:10.1186/s13104-022-06114-z
- Calonghi N, Parolin C, Sartor G, Verardi L, Giordani B, et al. Interaction of vaginal Lactobacillus strains with HeLa cells plasma membrane. Benef Microbes. 2017;8:625. doi:10.3920/BM2016.0212
- Terayama Y, Matsuura T, Uchida M, Narama I, Ozaki K. Probiotic (yogurt) containing Lactobacillus gasseri OLL2716 is effective for preventing Candida albicans-induced mucosal inflammation and proliferation in the forestomach of diabetic rats. Histol Histopathol. 2016;31:689. doi:10.14670/HH-11-710
- Mastromarino P, Brigidi P, Macchia S, Maggi L, Pirovano F, et al. Characterization and selection of vaginal Lactobacillus strains for the preparation of vaginal tablets. J Appl Microbiol. 2002;93:884.
